Posted by Osteogenesis Imperfecta (brittle bones)

cake โ›ฑ (side) (#54973)

Dreamboat of Ladies
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Posted on
2018-02-08 16:34:18
Please take caution if you go googling for OI - as always, medical images can be upsetting.

Taken from Wikipedia: Osteogenesis imperfecta (OI), also known as brittle bone disease, is a group of genetic disorders that mainly affect the bones. It results in bones that break easily. The severity may be mild to severe. Other symptoms may include a blue tinge to the whites of the eye, short height, loose joints, hearing loss, breathing problems, and problems with the teeth. Complications may include cervical artery dissection and aortic dissection.

Check out this neat visual... thing!
image.axd?picture=2017%2F6%2F%40shutterstock_248936854_(1).jpg
Source

For lions, this would be a lethal mutation - obviously! While there are multiple types of OI (at least nine), two are listed as lethal on the wikipedia but one is lethal during pregnancy, soooo...

Here is an idea for the lethal here, yoinked straight from the wikipedia.
Type II: Collagen is not of a sufficient quality or quantity.
Most cases die within the first year of life due to respiratory failure or intracerebral hemorrhage
Severe respiratory problems due to underdeveloped lungs
Severe bone deformity and small stature
Type II can be further subclassified into groups A, B, and C, which are distinguished by radiographic evaluation of the long bones and ribs. Type IIA demonstrates broad and short long bones with broad and beaded ribs. Type IIB demonstrates broad and short long bones with thin ribs that have little or no beading. Type IIC demonstrates thin and longer long bones with thin and beaded ribs.

But wait, I here you say, isn't this a human only thing?? Nope, again from the wiki!
In dogs, OI is an autosomal-recessive condition. In Golden Retrievers, it is caused by a mutation in the COL1A1, and in Beagles, the COL1A2. A separate mutation in the SERPINH1 gene has been found to cause the condition in Dachshunds.Several mouse models of OI have been described, whereby the abnormal gait 2 (AGA2) mouse line exhibits severe skeletal and cardio-pulmonary phenotypes due to a carboxy-terminus mutation in the COL1A1 gene in the mouse.

Appears: At birth
Affects Gameplay?: Yes, cub dies at 5 months (or earlier, I couldn't decide)
Lethal?: Yes

can i get uh....................... BONELESS CUB?

MUTATION SUGGESTIONS:
Spina Bifida [lethal] | Club foot | [YOU ARE HERE]
EYE SUGGESTIONS
Fruits for the Eyes | Assorted Eyes | Assorted Eyes: Part 2
MARKING SUGGESTIONS
November and Gem Markings | February and Gem Markings
Rosette Recolours | Giraffe and Inverted Giraffe
BASE SUGGESTIONS
Cake's Realistics | Cake's Semi-Realistics
Cake's Unrealistics | Cake's Combos
GENERAL SUGGESTIONS
Spoiler Button | Event Based Site Themes




This suggestion has 536 supports and 14 NO supports.



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Edited on 07/04/18 @ 06:39:16 by cake โ›ฑ (#53239)

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Ink ๐Ÿฆ (#79284)

King of the Jungle
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Posted on
2018-02-08 16:37:04
I love this idea! They pulled it off so well in the movie Unbreakable~
I support



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Haunt {gen1 murk
stellar} (#109396)

Interstellar
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Posted on
2018-02-08 16:37:50
*slams support button* I have(had? I don't have natural teeth anymore) dentinogenesis imperfecta and my uncle has OI. I'd love to see this mutation represented here.



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wreno ๐Ÿ“ (#134678)

Toxic
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Posted on
2018-02-10 15:30:10
Yes! Amazing idea!



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poison [MUSHISHI
STAN] (#130169)

Aztec Knight
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Posted on
2018-02-10 15:30:52
while it is a nice and unique idea, how would this affect the art? we cant just have a normal ass looking cub with a mutation i just dont think it would be something people want if its normal looking. i wont press either for now unless im given an idea of the art



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cake โ›ฑ (side) (#54973)

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Posted on
2018-02-10 15:32:24
@Poison
I mean, we didn't really need a new art pose for any of the mutations, but we got them so



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poison [MUSHISHI
STAN] (#130169)

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Posted on
2018-02-10 15:34:59
@cake fair point but we do have them so i think continuing the art exclusive to mutations would be fitting. but i think it would be a boring mutation without any special art.



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wreno ๐Ÿ“ (#134678)

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Posted on
2018-02-10 15:38:24
@poison I was browsing through some photos of the mutation, and mainly it was disfigured structure.

Referring to (a lil disturbing but to prove my point, little disturbing for the light hearted ):

http://dnadiseases.weebly.com/uploads/2/9/3/9/29392009/899047.jpg?280

http://2.bp.blogspot.com/-Gqujas4mAIg/VFJz2soC3cI/AAAAAAAACKk/k8UTb01NSuU/s1600/4_62_Alt2.jpg
----

So maybe they can have a more disfigured, curled body. The arms and legs seem to spread and curl together in the IRL photos:

IRL photo (no nudity, little disturbing for the light hearted ): https://ehealthwall.com/wp-content/uploads/2012/04/osteogenesis-imperfecta.jpg



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Edited on 10/02/18 @ 15:43:30 by cake โ›ฑ (side) (#54973)

cake โ›ฑ (side) (#54973)

Dreamboat of Ladies
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Posted on
2018-02-10 15:43:22
@poison if it gets added Xy will likely inevitably add it's own pose. Idk how to describe a pose that would make sense

@foretold: I removed that last link bc even tho it's a medical pic it's not safe for LD.



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wreno ๐Ÿ“ (#134678)

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Posted on
2018-02-10 15:43:54
m'kay! understandable xD



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poison [MUSHISHI
STAN] (#130169)

Aztec Knight
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Posted on
2018-02-10 15:45:18
oops late response, but okay! that could work if it was all disfigured and awkward looking.



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๐ŸˆFanta Denim๐Ÿˆ (#135329)

Deathlord of the Jungle
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Posted on
2018-03-02 15:09:55
B o n e l e s s p i z z a
This is a good lethal mutie idea!
Support!



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Fire ๐Ÿ”ฅ ๐Ÿ‡ต๐Ÿ‡ธ (#35734)

Interstellar
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Posted on
2018-03-02 15:10:03
Boneless cubs plz



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๐ŸˆFanta Denim๐Ÿˆ (#135329)

Deathlord of the Jungle
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Posted on
2018-03-02 15:10:44
@Fire
Boneless pizza cubs



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Black Rhinoceros (#68593)

Divine
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Posted on
2018-04-11 21:43:51
I love this idea!



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modacy (#134755)

Sapphic
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Posted on
2018-05-17 08:27:48
Yes! I was actually planning on suggesting this myself but looked to see if anyone else had first.



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