Posted by LCHAD - Lethal

āš”ļø Lunarknight
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Posted on
2019-06-20 19:35:42
Hiya. My inspiration for bringing up this disorder is the daughter of one of my close friends. It's a daily struggle but like the super-mom that she is her daughter is thriving. To help spread awareness of this little known disorder it'd be great if it was a mutation on here. Granted I don't know if lions can get it but who knows.. So far i haven't been able to find any non-human cases but we're both mammals so there's a chance it could happen to a lion cub. It'd definitely be placed in the lethal category. Probably death after 1-4 rollovers depending on how bad the condition is.

What does "LCHAD" mean?
* I got this from her LCHAD Awareness Facebook page *

A quick google search will tell you that LCHAD is an acronym. It is short for long-chain 3-hydroxyacyl-CoA dehydrogenase deficiency, but what does that actually mean? Most people understand about as much as "long chain... hydro... uhh... oxy... um..." So let's break this down and take a look at what we're really talking about.

LONG-CHAIN The food we eat contains certain types of fat, characterized by their structure. They are refered to as different "chains." The body first digests the sugars from our food, and then begins to break down the fats, beginning with the long-chain fats. The long-chain fats are broken down into medium-chain fats, and the medium-chain fats to short-chain fats.

3-HYDROXYACYL (hide-rock-see-ace-ill) COA DEHYDROGENASE is an enzyme involved in fatty acid metabolic processes. It is the actual substance that breaks down the long-chain fats described above.

The full name of the disorder is LCHAD DEFICIENCY. All together, this means that when a person has LCHAD, they do not have enough of the correct enzyme in their body to be able to process the fat found in the foods we eat.

How rare is LCHAD?
Nobody really knows for sure but it's been guessed at 1 out of at least 100,000 births. Until it was discovered and put on the pediatric checklist for newborns it was probably one of the causes of sudden Infant death syndrome(SIDS). A doctor can go their entire career without seeing a single LCHAD patient. The only way to know for sure if your child has it is by a blood and urine test since it shares some symptoms with other health issues that are more well known. It's recessive so both parents have to be a carrier. You can find out through a DNA test.

Signs and Symptoms
Some signs and symptoms of LCHAD deficiency typically appear during infancy or early childhood and can include feeding difficulties, lack of energy (lethargy), low blood sugar (hypoglycemia), weak muscle tone (hypotonia), liver problems, and abnormalities in the light-sensitive tissue at the back of the eye (retina). As the child ages there's a chance of vision problems and possibly eventual blindness

Helpful websites
Orpha.net
Living with LCHAD
Christopher's story
Owen's story (the life of a 2 year old with LCHAD. It's a short story so a quick read)

Cub appearance
There probably won't be much of a change. Maybe a lethargic looking pose and leaner looking than the original cub art. Most likely won't even need to worry about adult art since without human intervention the cub would barely survive the cub stage if at all. Keep in mind they're meat eaters and this is a enzyme disorder so their digestive track will be severely impaired among other things.

Birth Message

" After a difficult pregnancy, and time to rest afterwards, your lioness looks proudly at her litter. Upon a closer look she notices something off. One of the cubs is slightly smaller and weaker than the others. It's also nursing in short ,as well as very often, spans of time. She wonders if it'll make it or not."

LCHAD can be dangerous for the mother as it is for the baby. Without care mom could die due to the strain of the fatty acid oxidation disorder (FAOD) part of LCHAD. Now since it would make a lot of people unhappy if their favorite pixel lioness died randomly let's have her survive the ordeal. Instead of dieing she'll just be very tired after the cubs are born.

I'll be adding more as I get my research ducks in a row so this thread is currently a work in progress.


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Edited on 11/08/19 @ 20:06:35 by LunarKnight(Op. Heavy Pie) (#151072)

Luxray (#146182)

Cursed
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Posted on
2019-06-20 19:49:35
It sounds like it would be an invisible mutation, like deafness. Is that right? Supported either way, but I am curious.



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āš”ļø Lunarknight
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Posted on
2019-06-20 19:53:33
That's correct. My friend's daughter is on the small scale as far as size goes and her condition makes her unable to do a lot of exercise. There's going to be some in-game disadvantages and stat penalties too.



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āš”ļø Lunarknight
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Posted on
2019-06-20 20:01:05
I just added some of the common symptoms and signs.



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Beau (Frozen until
febuary) (#144085)

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Posted on
2019-06-20 20:02:38
I love this idea.
I like- no love- the fact it brings light to an otherwise unspoken issues. Iā€™m happy to see someone trying to help bring awareness.
Supported, a million times over.



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Blackthorn (#5838)

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Posted on
2019-06-20 20:09:20
What's scary is I actually understood all the science-y stuff without the explanation XD Support, because why not and it brings some attention on a real issue. I have a feeling this would seriously mess up (and likely does) ATP production (energy the body uses), because while your body does first go for carbohydrates (i.e. sugars) for that, it can process fats and proteins into the ATP cycle too. And if you can't process fats, you're either loosing out on a serious source or you're storing it and never using it. Fats are an important part of one's diet, which is why is actually not a good thing to cut them entirely out.
(Not at all sure about any of what I just said, but that's just from an educated guess as a biology student.)

Also, generally speaking with conditions like this, if affects a mammal it likely effects or could effect other mammals as well. As mammals, our metabolisms relatively work the same, if a bit different when it comes to efficiency and other minor changes. That's one of the main reasons at my college, no matter what kind of biology major you are (pre-vet, pre-med, environmental, etc.), everyone takes animal anatomy classes and cellular biology.



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āš”ļø Lunarknight
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Posted on
2019-06-20 20:20:29
@ Belle (Side!) (#144085)
Thanks. I know most people on here support visual mutations more than internal ones but can't blame a person for trying.

@ Blackthorn (#5838)
I appreciate the support and the fact you were able to understand it too. I grew up reading my grandmother's nursing and medical books. Lol. LCHAD puts a big strain on the body in general. They need a special powder just to help with digestion. I can't remember what my friend said it was called though.

Ah ok. I had a good idea it could but haven't been able to find any proof outside human cases.



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Edited on 20/06/19 @ 20:21:11 by DaemonFox(Side) *R.Ruby Ferus* (#150967)

āš”ļø Lunarknight
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Posted on
2019-06-20 20:41:19
Added a cub appearance section. It's still under construction as I'm checking my facts



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āš”ļø Lunarknight
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Posted on
2019-06-20 21:36:22
I'm compiling a list of helpful websites and , soon, real life stories. Feel free to click on them once added if curious or interested. ^_^



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šŸ—”ļø LunarKnight
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Posted on
2019-06-21 10:34:06
Just added a birth message section. It might need to be tweaked a bit but it's a start.



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Blackthorn (#5838)

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Posted on
2019-06-21 11:09:25
So I did some reading up on feline anatomy, and all I can find about digestion (what this would directly effect if I'm reading things right) is that they have a bit more simple version of a system compared to humans(that actually came out of my textbook and its specifically referencing lions), and essentially take in almost entirely just proteins, but fats do play a part in their nutrition still. They don't have anything odd that might bypass this. However, I'd actually have to question if this would be truly lethal for them, since their entire system responds to proteins not carbohydrates, but then nothing I'm reading refers to how they digest lipids (fats), just mentions they're important for their claws, fur, and skin. One of the reasons there likely aren't cases of this seen in felines is probably due to a low-fat high-protein diet (they are obligate carnivores and super picky about their food), but again, as I said, so much of the body in mammals requires fats (cell membranes, for example), I'd have a hard time believing cats could live without them. We are also talking in terms of wild animals, so any sort of disadvantage could be lethal. We have to remember our lions aren't getting hand-fed and receiving vet care or anything like that.



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Edited on 21/06/19 @ 11:10:13 by Blackthorn (#5838)

šŸ—”ļø LunarKnight
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Posted on
2019-06-21 12:08:51
That actually makes a lot of sense. You're right. I did some research on their prey of choice; I got curious. To my surprise even hippopotamus meat is low in fat. I honestly thought it'd be somewhat fatty but you can't judge a hippo by its look. Chances of a cub making it to adulthood with LCHAD could go either way now I think. Humans with it are allowed small portions of fat a day but the amount of grams depends on their weight and overall health.

Maybe move it off the cub lethal category and have it to where the lion can die at any time due to complications. They have to eat small and frequent meals every day which is what could potentially be the result of one dieing. Lionesses can't hunt or effectively protect cubs. Male's can't patrol or be kinged. What do you think?



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Edited on 21/06/19 @ 12:10:29 by LunarKnight(Op. Heavy Pie) (#151072)

āš”ļø Lunarknight
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Posted on
2023-01-30 22:41:38
My friends daughter passed away due to LCHAD related complications before Covid hit. Nobody saw it coming but it happened in her sleep. Her mother was extremely careful with everything but you can't escape fate. Her story is one of many short ones. I recently came back from a long hiatus. Her passing is part of the reason why I suddenly left along with other life related stuff.

If any of you reading this have children please give them all the love in your world. You never know when you'll loose them.



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